I-Cycobalamin ingenye ye-vitamin B complexes, enomphumela oqinile we-anti-pernicious anemia. Yigama elinikezwe icrystallization kavithamini B12, into ebaluleke kakhulu ekuthuthukisweni kwamagciwane nezilwane. Ngaphandle kuka-C, H, O, N, P kanye no-Co, i-ad-ribose conjugate ye-5,6-dimethe-rbenzimidazole iyingxenye yesakhiwo sayo. AR Todd et al. beka phambili ifomula yesakhiwo, ebizwa ngokuthi i-cyanocobalamin ngoba i-cyano ihlanganiswe ku-cobalt. Ukumuncwa okuphezulu kwesisombululo esinamanzi ngu-278,361,548 nm. Ngo-1948, u-E．L.Rickes wase-United States kanye no-E. Kusukela ngaleso sikhathi, le nto iye yatholakala ku-actinomycete ethile (StrePtomyces griseum).I-Cyanocobalamin futhi iyisici sokukhula kwezingulube namatshwele, futhi iyinto efanayo ne-protein factor yezilwane edingekayo ekuchamiseleni amaqanda. I-Vitamin B12, enikezwa iziguli ezinezifo eziyingozi kuma-micrograms angu-150, ingandisa amangqamuzana egazi abomvu cishe izikhathi ezingu-2, futhi ama-microgram angu-3-6 nawo angaveza imiphumela. Ku-vivo, ihanjiswa egazini ngendlela yokuhlanganiswa ne-trans-cobalamin protein (a-globular protein), futhi ikhona ngesimo se-coenzyme ezicutshini ezihlukahlukene. Kanye ne-folic acid, ibandakanyeka kumetabolism yokudluliselwa kwe-methyl kanye nesizukulwane se-methyl esisebenzayo. Futhi ube yisici esibalulekile se-purine, i-pyrimidine nezinye i-biosynthesis.
